High levels of uric acid in systemic lupus erythematosus is associated with pulmonary hypertension
Identifieur interne : 000F55 ( Main/Exploration ); précédent : 000F54; suivant : 000F56High levels of uric acid in systemic lupus erythematosus is associated with pulmonary hypertension
Auteurs : Ki-Jo Kim [Corée du Sud] ; In-Woon Baek [Corée du Sud] ; Yune-Jung Park [Corée du Sud] ; Chong-Hyeon Yoon [Corée du Sud] ; Wan-Uk Kim [Corée du Sud] ; Chul-Soo Cho [Corée du Sud]Source :
- International Journal of Rheumatic Diseases [ 1756-1841 ] ; 2015-06.
Abstract
Aim: To estimate the point prevalence of pulmonary hypertension (PH) and determine the associated factors for PH in patients with systemic lupus erythematosus (SLE). Methods: A prospective cross‐sectional study of 114 patients with SLE was conducted in a single tertiary center. Transthoracic echocardiography was performed to estimate the pulmonary arterial pressures. PH was defined as resting systolic pulmonary artery pressure (sPAP) ≥ 40 mmHg, in the absence of left heart disease. Results: PH was identified in nine patients (7.9%) who had few cardiopulmonary symptoms. SLE patients with PH had higher SLE disease activity index score. In particular, serum uric acid (UA) was significantly higher in patients with PH than in those without PH. In multivariate analysis, UA remained significant for the presence of PH. Moreover, serum UA level correlated significantly with plasma NT‐pro‐B‐type natriuretic peptide level as well as sPAP. At the cutoff level of 6.5 mg/dL, serum UA had reasonable accuracy for predicting the presence of PH in SLE patients (sensitivity 66.7% and specificity 96.2%). Conclusion: A significant number of SLE patients in rheumatology practice have undiagnosed PH with few discernible symptoms. Serum UA level may be useful as a surrogate marker for screening of PH in patients with SLE.
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DOI: 10.1111/1756-185X.12262
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type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Park, Yune Ung" sort="Park, Yune Ung" uniqKey="Park Y" first="Yune-Jung" last="Park">Yune-Jung Park</name><affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Yoon, Chong Yeon" sort="Yoon, Chong Yeon" uniqKey="Yoon C" first="Chong-Hyeon" last="Yoon">Chong-Hyeon Yoon</name><affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul</wicri:regionArea><placeName><settlement 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type="abstract">Aim: To estimate the point prevalence of pulmonary hypertension (PH) and determine the associated factors for PH in patients with systemic lupus erythematosus (SLE). Methods: A prospective cross‐sectional study of 114 patients with SLE was conducted in a single tertiary center. Transthoracic echocardiography was performed to estimate the pulmonary arterial pressures. PH was defined as resting systolic pulmonary artery pressure (sPAP) ≥ 40 mmHg, in the absence of left heart disease. Results: PH was identified in nine patients (7.9%) who had few cardiopulmonary symptoms. SLE patients with PH had higher SLE disease activity index score. In particular, serum uric acid (UA) was significantly higher in patients with PH than in those without PH. In multivariate analysis, UA remained significant for the presence of PH. Moreover, serum UA level correlated significantly with plasma NT‐pro‐B‐type natriuretic peptide level as well as sPAP. At the cutoff level of 6.5 mg/dL, serum UA had reasonable accuracy for predicting the presence of PH in SLE patients (sensitivity 66.7% and specificity 96.2%). Conclusion: A significant number of SLE patients in rheumatology practice have undiagnosed PH with few discernible symptoms. Serum UA level may be useful as a surrogate marker for screening of PH in patients with SLE.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Kim, Ki O" sort="Kim, Ki O" uniqKey="Kim K" first="Ki-Jo" last="Kim">Ki-Jo Kim</name></region><name sortKey="Baek, In Oon" sort="Baek, In Oon" uniqKey="Baek I" first="In-Woon" last="Baek">In-Woon Baek</name><name sortKey="Cho, Chul Oo" sort="Cho, Chul Oo" uniqKey="Cho C" first="Chul-Soo" last="Cho">Chul-Soo Cho</name><name sortKey="Cho, Chul Oo" sort="Cho, Chul Oo" uniqKey="Cho C" first="Chul-Soo" last="Cho">Chul-Soo Cho</name><name sortKey="Kim, Wan K" sort="Kim, Wan K" uniqKey="Kim W" first="Wan-Uk" last="Kim">Wan-Uk Kim</name><name sortKey="Park, Yune Ung" sort="Park, Yune Ung" uniqKey="Park Y" first="Yune-Jung" last="Park">Yune-Jung Park</name><name sortKey="Yoon, Chong Yeon" sort="Yoon, Chong Yeon" uniqKey="Yoon C" first="Chong-Hyeon" last="Yoon">Chong-Hyeon Yoon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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